Biosynthesis of Simocyclinone D8 in an 18O2-rich Atmosphere.
نویسندگان
چکیده
منابع مشابه
Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action.
We have characterized the interaction of a new class of antibiotics, simocyclinones, with bacterial DNA gyrase. Even though their structures include an aminocoumarin moiety, a key feature of novobiocin, coumermycin A(1), and clorobiocin, which also target gyrase, simocyclinones behave strikingly differently from these compounds. Simocyclinone D8 is a potent inhibitor of gyrase supercoiling, wit...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2002
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.55.341